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in 2011, and have already discovered two potential drugs that are active against hepatitis B.Getting close to the finish line “There has never been more optimism than right now that a cure is within reach,” said Block.In 2015, the Blumberg Institute licensed several of its discoveries to Arbutus Biopharma, the first company solely dedicated to hepatitis B drug discovery, and signed a three-year research agreement to work on novel approaches to developing a cure.“This unique partnership will allow us to move our discoveries more rapidly from the lab to the clinic,” Block explained.This is significant because inhibition of ccc DNA is considered essential in achieving a complete cure.Block is confident that a drug that can accomplish this will be developed.Experts believe a cure for hepatitis B will also soon be developed.

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“This is the goal of the Hepatitis B Foundation, so we are all very excited.” Blumberg researchers are building on recent discoveries that have heightened the momentum around finding a cure for hepatitis B and liver cancer: new screening methods to search for effective drugs; new ways to treat hepatitis B using different approaches to shut down the virus; a new blood biomarker that aids in the early detection of liver cancer; and a promising drug that selectively kills liver cancer cells in animal studies.

“The years that we all have spent working towards a cure for hepatitis B have laid the groundwork for this final phase,” said Block.

They have limited effectiveness against ccc DNA, the seemingly indestructible “mini-chromosome” of the hepatitis B virus that continues to produce virus particles in infected liver cells, even in people being treated.

A cure, therefore, would have to destroy or silence ccc DNA and provide long-term immunity.

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